汤道权

个人简历

江苏高校青蓝工程中青年学术带头人、江苏省六大人才高峰高层次人才。全国高等教育医学会药学分会委员，江苏省药理学会理事，江苏省高等学校医药教育研究会理事，徐州药学会常务理事，淮海科技奖专家库成员，徐州市应急管理专家组成员。主要从事中药及体内药物分析。主持完成及在研省级科技项目5项、市厅级科技计划项目5项；获市厅级科技进步一等奖3项、三等奖2项（均排名第1）；累计发表SCI收录论文60余篇；授权发明专利3项。

承担科研课题

1. 江苏省中医药管理局专题研究项目，ZT202212，基于“宿主-肠道微生物”共代谢的六味地黄丸对DN的改善作用及分子机制研究，2023.01-2025.12，24万元，项目主持人

2. 徐州市科技计划项目，KC21204，基于代谢组学和微生物组学的二甲双胍联合桑叶对T2D的治疗作用及潜在机制研究，2021.07-2023.06，5万元，项目主持人

3. 江苏省自然科学基金社会发展项目，BE2019640，癫痫类药物治疗药物监测技术的构建及其在个体化治疗中的应用，2019.07-2022.06，50万元，项目主持人。

4. 江苏省自然科学基金面上项目，BK20181147，抗癫痫药物HS-SPE/GC-MS分析方法的构建及其在临床血药浓度监测中的应用，2018.07-2021.06，10万元，项目主持人。

5. 徐州市自然科学基金，KC17187，石墨烯量子点/分子印迹聚合物复合膜的构建及其在卡马西平/奥卡西平精准药物治疗中的应用，2017.09-2020.08，5万元，项目主持人。

6. 江苏省高校自然科学基金重大项目，16KJA350001，细胞动态代谢组学探寻糖尿病肾病形成过程的生物标志物，2016.09-2019.08，30万元，项目主持人。

7. 江苏省人力资源与社会保障厅第九批六大人才高峰项目，2012-YY-013，靶细胞萃取结合HPLC-DAD-MS/MS筛选银杏叶提取物防治糖尿病肾病的活性成分，2013.01-2015.12，3.0万元，项目主持人。

8. 江苏省自然科学基金面上项目，BK2011211，基于固化HSA\AGP\CM亲和色谱技术的银杏叶提取物防治糖尿病肾病的药效物质基础研究，2011.10-2013.12，8.0万元，项目主持人。

9. 徐州市战略性新兴产业发展专项引导资金计划项目，XX10A068，银杏叶提取物制备新工艺及质量控制新模式研究，2010.10-2012.12，3.0万元，项目主持人。

近五年代表性论文、专著

1. Du Y, Li DX, Lu DY Zhang R, Zhao YL, Zhong QQ, Ji S, Wang L, Tang DQ*. Lipid metabolism disorder and lipid mediator changes of mice in response to long-term exposure to high-fat and high sucrose diet and ameliorative effects of mulberry leaf. Food Funct. 2022, 13(8):4576-4591.  IF:6.317

2. Lu YF, Li DX, Zhang R, Zhao LL, Qiu Z, Du Y, Ji S, Tang DQ*. Chemical Antioxidant Quality Markers of Chrysanthemum morifolium Using a Spectrum-Effect Approach. Front Pharmacol. 2022; 13:809482. IF:5.998

3. Du Y, Li DX, Lu DY, Zhang R, Zhong QQ, Zhao YL, Zheng XX, Ji S, Wang L, Tang DQ*. Amelioration of lipid accumulations and metabolism disorders in differentiation and development of 3T3-L1 adipocytes through mulberry leaf water extract. Phytomedicine. 2022; 98:153959.  IF:6.656

4. Du Y, Li DX, Lu DY, Zhang R, Zheng XX, Xu BJ, Zhao YL, Ji S, Guo MZ, Wang L, Tang DQ*. Morus alba L. water extract changes gut microbiota and fecal metabolome in mice induced by high-fat and high-sucrose diet plus low-dose streptozotocin. Phytother Res. 2022; 36(3):1241-1257.  IF:6.388

5. Ji S*, Zhu C, Gao S, Shao X, Chen X, Zhang H, Tang D*. Morus alba leaves ethanol extract protects pancreatic islet cells against dysfunction and death by inducing autophagy in type 2 diabetes. Phytomedicine. 2021; 83:153478.  IF:6.656

6. Wang M, Liu Q, Kang X, Zhu Z, Yang H, Xi X, Zhang X, Du Y, Guo M, Tang D*, Wang L*. Glycogen Metabolism Impairment via Single Gene Mutation in the glgBXCAP Operon Alters the Survival Rate of Escherichia coli Under Various Environmental Stresses. Front Microbiol. 2020; 11:588099.  IF:6.064

7. Ji S*, Wang YJ, Shao X, Zhu CC, Lin Y, Gao SK, Tang DQ*. Extraction and purification of triterpenoid saponins from licorice by ionic liquid based extraction combined with in situ alkaline aqueous biphasic systems. Sep Purif Technol. 2020; 247:116953.  IF:9.136

8. Zhang L, Wang CX, Wu J, Wang TY, Zhong QQ, Du Y, Ji S, Wang L, Guo MZ, Xu SQ, Tang DQ*. Metabolic profiling of mice plasma, bile, urine and feces after oral administration of two licorice flavonones. J Ethnopharmacol. 2020; 257:112892.  IF:5.195

9. Guo M, Du W, Lyu N, Chen X, Du Y, Wang H, Yang D, Wu S, Liang J, Pan Y, Tang D. Ultra-Early Diagnosis of Acute Myocardial Infarction in Rats Using Ultrasound Imaging of Hollow Double-Layer Silica Nanospheres. Adv Healthc Mater. 2020; 9(3):e1901155.  IF:11.092

10. Ji S, Wang YJ, Gao SK, Shao X, Cui W, Du Y, Guo MZ, Tang DQ*. Highly efficient and selective extraction of minor bioactive natural products using pure ionic liquids: Application to prenylated flavonoids in licorice. J Ind Eng Chem. 2019; 80:352-360.  IF:6.76

11. Wang L, Du Y, Xu BJ, Deng X, Liu QH, Zhong QQ, Wang CX, Ji S, Guo MZ, Tang DQ. Metabolomics study of metabolic changes in renal cells in response to high-glucose exposure based on liquid or gas chromatography coupled with mass spectrometry. Front Pharmacol. 2019; 10:928.  IF:5.998

12. Guo MZ, Shao L, Chen X, Li HJ, Wang L, Pan YJ, Tang DQ*. Assay of dried blood spot from finger prick for sodium valproate via ink auxiliary headspace gas chromatography mass spectrometry. J Chromatogr A. 2019; 1601:335-339.  IF: 4.601

13. Guo M, Shao L, Du Y, Qian Z, Huang T, Tang D*. Microporous polymer based on the new compound "bi-(4-vinyl phenylquinoline) amide" for enrichment and quantitative determination of lamotrigine in rat and human serum. Anal Bioanal Chem. 2019; 411(15):3353-3360.  IF:4.478

14. Ji S, He DD, Su ZY, Du Y, Wang YJ, Gao SK, Guo MZ, Tang DQ*. P450 enzymes-based metabolic interactions between monarch drugs and the other constituent herbs: A strategy to explore compatibility mechanism of Sangju-Yin. Phytomedicine. 2019; 58:152866.  IF:6.656

15. Guo MZ, Wang TY, Yang J, Chang H, Ji S, Tang DQ*. Interaction of clopidogrel and fufang danshen dripping pills assay in coronary heart disease based on non-target metabolomics. J Ethnopharmacol. 2019; 234:189-196.  IF:5.195

16. Ji S, Liu ZZ, Wu J, Du Y, Su ZY, Wang TY, Han J, Yang DZ, Guo MZ, Tang DQ*. Chemical profiling and comparison of Sangju Ganmao tablet and its component herbs using two-dimensional liquid chromatography to explore compatibility mechanism of herbs. Front Pharmacol. 2018; 9:1167. IF:5.998

17. Guo MZ, Zhang LY, Du Y, Du WC, Liu DT, Guo C, Pan YJ, Tang DQ*. Enrichment and quantitative determination of 5-(hydroxymethyl)-2'-deoxycytidine, 5-(formyl)-2'-deoxycytidine, and 5-(carboxyl)-2'-deoxycytidine in human urine of breast cancer by magnetic high-cross-linked microporous polymers based on poly-ionic liquid. Anal Chem. 2018; 90(6):3906-3913.  IF:8.008