张彦卓

个人简历

毕业于沈阳药科大学药剂学专业，致力于新型响应性仿生传递系统研究和新型长效制剂及改良制剂应用研究。十三五国家科技重大专项课题负责人，具有丰富的新药及仿制药研发经验和良好的工作基础。承担本科《药剂学》等课程教学工作。主持完成国家自然科学基金1项，江苏省自然科学基金1项，参与多项创新药研发。以通讯作者或第一作者发表SCI论文在J Control Release、Mol Pharmaceutics等制剂学专业期刊，最高影响因子7.9，单篇他引百余次。已带教硕士生10余人，毕业6人，授权国家发明专利1项。入选江苏省创新创业人才计划及江西省科技厅科技专家库评审专家。

承担科研课题

1.    国家新药创制重大专项课题，2019ZX09302033，临床亟需儿童药品醋酸氟氢可的松研究开发，2019.01-2020.12，453万元，主持。

2.    国家自然科学基金，81402879，基于介孔碳支撑磷脂双分子层的难溶性药物口服纳米给药系统的构建及其性能研究，2015.01-2017.12，23万元，主持。

3.    江苏省自然科学基金，BK20140221，介孔碳-磷脂双分子层口服纳米给药系统的制备与评价，2014.07-2017.07，20万元，主持。

近五年代表性论文、专著

1.    Xiaonan Li, Ziming Zhao, Yihua Yang, Zhaorong Liu, Jinglei Wang, Yalu Xu, Yanzhuo Zhang. Novel b-1,3-D-glucan porous microcapsule enveloped folate-functionalized liposomes as a Trojan horse for facilitated oral tumor-targeted co-delivery of chemotherapeutic drugs and quantum dots. J Mater Chem B. 2020, DOI: 10.1039/c9tb02674f.

2.    Jing Wang, Fang Wang, Xiaonan Li, Yang Zhou, Hongtao Wang, Yanzhuo Zhang. Uniform carboxymethyl chitosan-enveloped Pluronic F68/poly(lactic-co-glycolic acid) nano-vehicles for facilitated oral delivery of gefitinib, a poorly soluble antitumor compound. Colloid. Surface. B. 2019, 170:425–432.

3.    Xiaonan Li, Jinglei Wang, Fang Wang, Yang Zhou, Hongtao Wang, Yanzhuo Zhang. Development and evaluation of multifunctional poly(lactic-co-glycolic acid) nanoparticles embedded in carboxymethyl beta-glucan porous microcapsules as a novel drug delivery system for gefitinib. Pharmaceutics. 2019, 11:9.

4.    Yanzhuo Zhang, K Dong, F Wang, H Wang, J Wang Ziqiu Jiang, Shuai Diao. Three dimensional macroporous hydroxyapatite/chitosan foam-supported polymer micelles for enhanced oral delivery of poorly soluble drugs. Colloid. Surface. B. 2018, 170:490–504. 

5.    Yanzhuo Zhang, Wufu Zhu, Heran Zhang, Jin Han, Lihua Zhang, Qisi Lin, Fengwei Ai. Carboxymethyl chitosan/phospholipid bilayer-capped mesoporous carbon nanoparticles with pH-responsive and prolonged release properties for oral delivery of the. Inter J Pharm. 2017, 532:384-392.