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邱净英

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发布时间:2020年05月26日
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邱净英,副教授,博士,硕士生导师

科学研究方向

抗病毒药物分子的设计、合成及生物活性研究

联系方式

电 话:0516-83262138

Emailjingyqiu@xzhmu.edu.cn

通 讯:江苏省徐州市云龙区铜山路209号,221004

个人简历

2006年毕业于沈阳药科大学,获理学学士学位,2012年毕业于贵州大学(贵州省中国科学院天然产物化学重点实验室),获理学博士学位,同年进入威廉公司官网药物分析教研室任职。2020年于美国明尼苏达大学交流访学一年。近年来研究方向为抗病毒药物分子的设计、合成及生物活性研究,先后主持国家自然科学基金青年基金、江苏省自然科学基金青年基金、江苏省自然科学基金面上项目等科研项目。以第一或通讯作者在European Journal of Medicinal ChemistryBioorganic & Medicinal Chemistry等杂志发表SCI论文20余篇,申请专利4项(已授权2项)。主要承担研究生《药物光谱分析选论》以及药学、临床药学、药物制剂等本科专业《药物分析》、《分析化学》等课程的理论及实验教学。

承担科研课题

1. 国家自然科学基金青年基金项目,81703359,基于药效团融合的新型抗HBV药物的设计、合成及生物活性研究,2018-012020-1219.9万元,主持;

2. 江苏省自然科学基金面上项目,BK20181151,具有双重作用机制的药效团融合型抗HBV化合物的设计、合成及生物活性研究,2018-072021-0610万元,主持;

3. 江苏省自然科学基金青年基金项目,BK20140223,多靶点抗乙肝病毒药物的设计、合成及生物活性研究,2014-072017-0720万元,主持;

4. 徐州市科技计划项目,靶向核心蛋白和TLR7/8的新型喹唑啉酮类化合物的设计、合成及抗HBV活性研究,KC210116万元,2021-092023-08,主持;

5. 徐州医学院优秀人才科研启动基金,新型苯基丙酰胺类化合物的设计、合成及抗HBV活性研究,2013.06-2016.0610万元,主持。

近五年代表性论文、专著

1. Jingying Qiu#, Yueting Zou#, Shuqiong Li, Lihua Yang, Zibin Qiu, Fanyun Kong*, Xiaoke Gu*, Discovery of benzimidazole substituted 1, 2, 4-oxadiazole compounds as novel anti-HBV agents with TLR8-agonistic activities, European Journal of Medicinal Chemistry, 2022, 244, 114833.

2. Jingying Qiu#, Qingqing Zhou#,Yueting Zou, Shuqiong Li, Lihua Yang, Wang Chen, Jian Gao**, Xiaoke Gu*, Design and synthesis of novel quinazolinone derivatives as anti-HBV agents with TLR8 agonist effect, European Journal of Medicinal Chemistry, 2022, 231, 114159.

3. Jingying Qiu#, Yueting Zou#, Qingchuan Liu, Chunyu Jiang, Qingqing Zhou, Shuqiong Li, Wang Chen, Zheng Li, Xiaoke Gu*, Synthesis and evaluation of novel quinazolinone derivatives as potential anti-HCC agents, Chemistry & Biodiversity, 2022, 19(2): e202100766.

4. Xiaoke Gu#, Yinpeng Zhang#, Yueting Zou, Xin Li, Mingyu Guan, Qingqing Zhou, Jingying Qiu*, Synthesis and evaluation of new phenyl acrylamide derivatives as potent non-nucleoside anti-HBV agents, Bioorganic & Medicinal Chemistry, 2021, 29:115892.

5. Xiaoke Gu#, *, Mingyu Guan#, Chunyu Jiang, Qinghua Song, Xin Li, Nan Sun, Jing Chen, Jingying Qiu*. Assessment of Thiosemicarbazone-Containing Compounds as Potential Antileukemia Agents against P-gp Overexpressing Drug Resistant K562/A02 Cells, Chemistry & Biodiversity, 2021, 18(2): e2000775.

6. Jingying Qiu#, Qingqing Zhou#, Yinpeng Zhang, Mingyu Guan, Xin Li, Yueting Zou, Xuan Huang, Yali Zhao, Wang Chen, Xiaoke Gu*, Discovery of novel quinazolinone derivatives as potential anti-HBV and anti-HCC agents, European Journal of Medicinal Chemistry, 2020, 205:112581.

7. Xiaoke Gu#, *, Xin Li#, Mingyu Guan, Chunyu Jiang, Qinghua Song, Nan Sun, Yueting Zou, Qingqing Zhou, Jing Chen, Jingying Qiu*, Discovery of thiosemicarbazone-containing compounds with potent anti-proliferation activity against drug-resistant K562/A02 cells, Bioorganic & Medicinal Chemistry Letters, 2020, 30(24): 127638.

8. Xiaoke Gu#, *, Jing Chen#, Yinpeng Zhang, Mingyu Guan, Xin Li, Qingqing Zhou, Qinghua Song, Jingying Qiu*, Synthesis and assessment of phenylacrylamide derivatives as potential anti-oxidant and anti-inflammatory agents, European journal of medicinal chemistry, 2019, 180: 62-71.

9. Jingying Qiu#, Wang Chen#, Yinpeng Zhang, Qingqing Zhou, Jing Chen, Lihua Yang, Jian Gao*, Xiaoke Gu*, Daoquan Tang*, Assessment of quinazolinone derivatives as novel non-nucleoside hepatitis B virus inhibitors, European Journal of Medicinal Chemistry, 2019, 176: 41-49.

10. Xiaoke Gu#, *, Yanfei Jiang#, Jing Chen, Yinpeng Zhang, Mingyu Guan, Xin Li, Qingqing Zhou, Qian Lu, Jingying Qiu*, Xiaoxing Yin*, Synthesis and biological evaluation of bifendate derivatives bearing acrylamide moiety as novel antioxidant agents, European Journal of Medicinal Chemistry, 2019, 162: 59-69.

11. Jingying Qiu#, Qineng Gong#, Jian Gao, Wang Chen, Yinpeng Zhang, Xiaoke Gu*, Daoquan Tang*, Design, synthesis and evaluation of novel phenyl propionamide derivatives as non-nucleoside hepatitis B virus inhibitors, European Journal of Medicinal Chemistry, 2018, 144: 424-434.

12. Jingying Qiu#, Wang Chen#, Yanfei Jiang, Jing Chen, Yinpeng Zhang, Xiaoke Gu*, Assessment of a bifendate derivative bearing 6,7-dihydro-dibenzo[c,e]azepine scaffold as a potential anti-metastatic agent, MedChemComm, 2018, 9(11): 1826-1830.